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. 2004 Feb;190(2):435-41.
doi: 10.1016/j.ajog.2003.08.006.

Pregnancies in Gaucher disease: a 5-year study

Yonatan Elstein  1 , Vered Eisenberg, Sorina Granovsky-Grisaru, Ron Rabinowitz, Arnon Samueloff, Ari Zimran, Deborah Elstein
Affiliations

Pregnancies in Gaucher disease: a 5-year study

Yonatan Elstein et al. Am J Obstet Gynecol. 2004 Feb.

Abstract

Objective: The study was undertaken to investigate the outcome of pregnancies in Gaucher disease, particularly in enzyme-treated women.

Study design: A retrospective study was performed of pregnant women evaluated at a referral clinic.

Results: There were 43 (17 treated, 26 untreated) women with 66 pregnancies (23 treated, 43 untreated). The live birth rate was 78.3% among treated, 86.0% among untreated. One treated woman had three spontaneous abortions; 3 untreated women had one each. Four pregnancies in each group had postpartum bleeding, 7 requiring transfusions. Postpartum infections were prevalent among treated. Cesarean sections were generally for historic reasons. There was no exacerbation of Gaucher disease, except one bone crisis.

Conclusion: Most untreated women with milder disease enjoyed an uncomplicated course. Enzyme-treated patients (ie, with more severe disease) had more bleeding and infections post partum, but few had spontaneous abortions. Hematologic consultation is recommended. A review of world experience with pregnant patients with Gaucher disease is included.

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