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Clinical Trial
. 2004 Mar;48(3):1051-4.
doi: 10.1128/AAC.48.3.1051-1054.2004.

Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers

I M Rigter  1 , H G Schipper, R P Koopmans, H J M van Kan, H W Frijlink, P A Kager, H-J Guchelaar
Affiliations
Clinical Trial

Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers

I M Rigter et al. Antimicrob Agents Chemother. 2004 Mar.

Abstract

This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-beta-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.

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Figures

FIG. 1.
FIG. 1.
ABZSX concentration-versus-time curves for subject J after administration of a single dose of 800 mg of albendazole (given as a cyclodextrin solution, an arachis oil-polysorbate 80 suspension, a tablet, and a suppository).
FIG. 2.
FIG. 2.
Cmax and AUC0- 52 values for ABZX in 10 healthy subjects (subjects a to j) after administration of a single dose of 800 mg of albendazole (given as a tablet, an arachis oil-polysorbate 80 suspension, and a cyclodextrin solution).
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