Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Mar;11(3):214-8.
doi: 10.1038/nsmb729.

RNase III enzymes and the initiation of gene silencing

Michelle A Carmell  1 , Gregory J Hannon
Affiliations
Review

RNase III enzymes and the initiation of gene silencing

Michelle A Carmell et al. Nat Struct Mol Biol. 2004 Mar.

Abstract

Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Recently, a related RNAse III enzyme, Drosha, has surfaced as another component of the RNAi pathway. In addition to biochemistry, protein structures have proven to be helpful in deciphering the enzymology of RNase III molecules.

PubMed Disclaimer

LinkOut - more resources