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. 2004 Mar;24(3):175-80.
doi: 10.1038/sj.jp.7211068.

Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia

Daniel K Benjamin  1 , Elizabeth DeLong, Charles M Cotten, Harmony P Garges, William J Steinbach, Reese H Clark
Affiliations

Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia

Daniel K Benjamin et al. J Perinatol. 2004 Mar.

Abstract

Objective: To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture.

Study design: Multicenter cohort study of premature infants.

Results: First blood culture was negative for 4648/5497 (78%) of the neonates--390/4648 (8%) died prior to discharge. Mortality prior to discharge was 19% in the 161 infants with Gram-negative rod (GNR) bacteremia, 8% in the 854 neonates with coagulase negative staphylococcus (CONS), 6% in the 169 infants infected with other Gram-positive bacteria (GP-o), and 26% in the 115 neonates with candidemia. The excess 7-day mortality was 0% for Gram-positive organisms and 83% for GNR bacteremia and candidemia. Using negative blood culture as referent, GNR [hazard ratio (HR)=2.61] and candidemia (HR=2.27) were associated with increased mortality; CONS (HR=1.08) and GP-o (HR=0.97) were not.

Conclusions: Nosocomial GNR bacteremia and candidemia were associated with increased mortality but Gram-positive bacteremia was not.

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