The inositol 1,4,5-trisphosphate receptor--transcriptional regulation and modulation by phosphorylation

Abstract

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular membrane calcium channels essential for the release of calcium from intracellular stores. They form pathways for Ca2+ release that amplifies signals transmitted via plasma membrane receptors and so mediate a large array of calcium-regulated signal transduction events, from control of gene expression, through regulation of cell proliferation and other functions, to cell death. Molecular properties, expression and regulation of IP3Rs have been recently reviewed by others and thus these aspects will be mentioned only briefly in this article. This minireview will focus on the transcriptional regulation of IP3Rs and their modulation by phosphorylation.