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. 2004 Mar 4;6(5):779-82.
doi: 10.1021/ol036446c.

A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N Sonnenschein  1 , Jarrett J Farias, Karen Tenney, Susan L Mooberry, Emil Lobkovsky, Jon Clardy, Phillip Crews
Affiliations

A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N Sonnenschein et al. Org Lett. .

Abstract

A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here. [structure: see text]

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