doi: 10.1016/j.farmac.2003.11.005.
Synthesis and cytotoxic effect of carbocyclic potential minor groove binders
Affiliations
- PMID: 14987984
- DOI: 10.1016/j.farmac.2003.11.005
Item in Clipboard
Synthesis and cytotoxic effect of carbocyclic potential minor groove binders
Farmaco.
2004 Mar.
Abstract
New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.
Similar articles
-
Carbocyclic Analogues of Distamycin and Netropsin.Mini Rev Med Chem. 2019;19(2):98-113. doi: 10.2174/1389557518666181009143203. Mini Rev Med Chem. 2019. PMID: 30626311 Review.
-
Synthesis and biological activity of some new 5'-O-acyl tiazofurin derivatives.Eur J Med Chem. 2006 Apr;41(4):503-12. doi: 10.1016/j.ejmech.2006.01.005. Epub 2006 Mar 7. Eur J Med Chem. 2006. PMID: 16519966
-
Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.Eur J Med Chem. 2004 Jan;39(1):99-105. doi: 10.1016/j.ejmech.2003.11.005. Eur J Med Chem. 2004. PMID: 14987838
-
Anticancer cyclometalated [Au(III)m(C(wedge)N(wedge)C)mL]n+ compounds: Synthesis and cytotoxic properties.Chemistry. 2006 Jul 5;12(20):5253-66. doi: 10.1002/chem.200600117. Chemistry. 2006. PMID: 16642532
-
The chemistry of 2-aminocycloalkanecarboxylic acids.Chem Rev. 2001 Jul;101(7):2181-204. doi: 10.1021/cr000456z. Chem Rev. 2001. PMID: 11710244 Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
