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. 2004 Mar;59(3):211-4.
doi: 10.1016/j.farmac.2003.11.005.

Synthesis and cytotoxic effect of carbocyclic potential minor groove binders

Danuta Bartulewicz  1 , Tomasz Anchim, Milena Dabrowska, Krystyna Midura-Nowaczek
Affiliations

Synthesis and cytotoxic effect of carbocyclic potential minor groove binders

Danuta Bartulewicz et al. Farmaco. 2004 Mar.

Abstract

New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.

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