Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Apr;10(4):363-4.
doi: 10.1038/nm1004. Epub 2004 Feb 29.

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

Vicente E Torres  1 , Xiaofang Wang, Qi Qian, Stefan Somlo, Peter C Harris, Vincent H Gattone 2nd
Affiliations

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

Vicente E Torres et al. Nat Med. 2004 Apr.

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2(-/tm1Som)), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function.

PubMed Disclaimer

Publication types

LinkOut - more resources