Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2004 Mar;55(3):443-6.
doi: 10.1002/ana.20063.

A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease

Daniel G Healy  1 , Patrick M Abou-Sleiman, Tetsutaro Ozawa, Andrew J Lees, Kailash Bhatia, Kourosh R Ahmadi, Ullrich Wullner, Jose Berciano, J Carsten Moller, Christoph Kamm, Katrin Burk, Paolo Barone, Eduardo Tolosa, Niall Quinn, David B Goldstein, Nicholas W Wood
Affiliations
Comparative Study

A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease

Daniel G Healy et al. Ann Neurol. 2004 Mar.

Erratum in

  • Ann Neurol. 2004 Aug;56(2):311. Barrone P [corrected to Barone P]

Abstract

A functional --1021C --> T polymorphism in the dopamine beta-hydroxylase gene has been demonstrated to regulate plasma DBH activity. We report that individuals with genetically determined low serum DBH activity (genotype T/T) have protection against Parkinson's disease (p = 0.01). In particular, we observed an underrepresentation of the T/T genotype odds ratio = 0.46 (CI = 0.27-0.8). Rather than identifying a haplotype, or a marker in linkage disequilibrium with the risk variant, this to our knowledge is the first report directly linking PD susceptibility with a proven functional variant.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources