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Review
. 2001 Dec;1(5):282-7.

Accessory proteins in the biogenesis of G protein-coupled receptors

J C Bermak  1 , Q Y Zhou
Affiliations
  • PMID: 14993367
Review

Accessory proteins in the biogenesis of G protein-coupled receptors

J C Bermak et al. Mol Interv. 2001 Dec.

Abstract

Intracellular accessory proteins can be critical for G protein-coupled receptor (GPCR) biogenesis, including aspects of GPCR trafficking. Recent discoveries include the identification of multiple membrane-associated proteins that dictate not only the intracellular sequestration and/or transport of GPCRs, but also modulate-quite dramatically-GPCR ligand specificity subsequent to delivery to the cell surface. These exciting discoveries have shifted earlier paradigms of GPCR functionality.

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