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Review
. 2003 Mar;3(2):72-5, 50.
doi: 10.1124/mi.3.2.72.

Knockout mouse points to second form of tryptophan hydroxylase

Jeremy Veenstra-VanderWeele  1 , Edwin H Cook Jr
Affiliations
Review

Knockout mouse points to second form of tryptophan hydroxylase

Jeremy Veenstra-VanderWeele et al. Mol Interv. 2003 Mar.

Abstract

A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1(-/-) mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.

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