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. 2004 Feb;70(2):171-3.
doi: 10.1055/s-2004-815496.

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Joong Sup Shim  1 , Jin Hee Kim, Jiyong Lee, Si Na Kim, Ho Jeong Kwon
Affiliations

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata

Joong Sup Shim et al. Planta Med. 2004 Feb.

Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

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