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. 2004 Jan;83(1):91-3.
doi: 10.1023/B:BREA.0000010697.49896.03.

Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers

Annegien Broeks  1 , Lot de Witte, Anke Nooijen, Angelina Huseinovic, Jan G M Klijn, Flora E van Leeuwen, Nicola S Russell, Laura J van't Veer
Affiliations

Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers

Annegien Broeks et al. Breast Cancer Res Treat. 2004 Jan.

Abstract

We detected a significant excess risk for CHEK2*1100delC mutation carriers to develop a contralateral breast tumor, OR = 6.5 (95% CI 1.5-28.8, p = 0.005). The highest percentage of mutation carriers was detected among those bilateral breast cancer patients who had received radiation treatment for their first breast tumor. These results warrant prolonged medical surveillance and may indicate a clinically important interaction between CHEK2 heterozygosity and radiation in the development of contralateral breast cancer.

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