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. 2004 Feb;69(2):176-80.
doi: 10.1023/b:biry.0000018948.04559.ab.

Increased level of beta-amyloid in the brain of bulbectomized mice

I Yu Aleksandrova  1 , V V Kuvichkin, I A Kashparov, N I Medvinskaya, I V Nesterova, S M Lunin, A N Samokhin, N V Bobkova
Affiliations

Increased level of beta-amyloid in the brain of bulbectomized mice

I Yu Aleksandrova et al. Biochemistry (Mosc). 2004 Feb.

Abstract

Six weeks after bilateral olfactory bulbectomy, a peptide with molecular weight of 4 kD was revealed in extracts of the neocortex and hippocampus from mice. Using monoclonal antibodies 4G8, this peptide was identified as beta-amyloid. Its level was significantly higher in the bulbectomized animals than in sham-operated mice. The bulbectomized mice displayed sharp impairment in spatial memory when tested in the Morris water maze. The results suggest that bulbectomy initiates in the brain a pathological process similar to human Alzheimer's disease in location, biochemistry, and behavioral manifestations.

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