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. 1992 Sep;60(9):3921-4.
doi: 10.1128/iai.60.9.3921-3924.1992.

Identification of an acute-phase reactant in murine infections with Trypanosoma brucei

S Z Shapiro  1 , S J Black
Affiliations

Identification of an acute-phase reactant in murine infections with Trypanosoma brucei

S Z Shapiro et al. Infect Immun. 1992 Sep.

Abstract

A 42-kDa protein appeared at a much higher concentration in plasma from Trypanosoma brucei-resistant (C57BL/6) mice after infection than in plasma from trypanosome-susceptible (C3H/He) mice. This protein was purified by sequential steps of gel filtration, protein A-Sepharose affinity chromatography, isoelectric focusing, and ammonium sulfate precipitation. The purified protein was identified as a subunit of the acute-phase reactant haptoglobin. Causes of elevated plasma haptoglobin and its implications for resistance to trypanosomiasis are discussed.

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