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. 2004 Mar;42(3):1341-4.
doi: 10.1128/JCM.42.3.1341-1344.2004.

Human papillomavirus, cytomegalovirus, and adeno-associated virus infections in pregnant and nonpregnant women with cervical intraepithelial neoplasia

M Grce  1 , K Husnjak, M Matovina, N Milutin, L Magdic, O Husnjak, K Pavelic
Affiliations

Human papillomavirus, cytomegalovirus, and adeno-associated virus infections in pregnant and nonpregnant women with cervical intraepithelial neoplasia

M Grce et al. J Clin Microbiol. 2004 Mar.

Abstract

Two hundred eight cervical specimens from two groups of subjects, 165 nonpregnant women and 53 pregnant women with cervical intraepithelial neoplasia (CIN) of grades I to III, were positive by PCR analyses for human papillomaviruses (HPVs), adeno-associated virus type 2 (AAV 2), and human cytomegalovirus (HCMV) in 67, 6, and 4.1% of the cases, respectively. The presence of AAV 2 infection was more frequently associated with pregnancy (17 versus 2.4%) and HPV-positive cervices (odds ratio = 6.358) than HCMV was. Increased HPV infection was strongly associated (P < 0.001) with a higher CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on CIN development.

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Figures

FIG. 1.
FIG. 1.
Distributions of different HPV genotypes among nonpregnant (A) and pregnant women (B) according to CIN grade.
See this image and copyright information in PMC

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