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Review
. 2004 Mar;26(3):233-48.
doi: 10.1385/MB:26:3:233.

PNA Technology

Peter E Nielsen  1
Affiliations
Review

PNA Technology

Peter E Nielsen. Mol Biotechnol. 2004 Mar.

Abstract

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]), and PNA oligomers are able to form very stable duplex structures with Watson-Crick complementary DNA and RNA (or PNA) oligomers, and they can also bind to targets in duplex DNA by helix invasion. Therefore, these molecules are of interest in many areas of chemistry, biology, and medicine, including drug discovery, genetic diagnostics, molecular recognition, and the origin of life. Recent progress in studies of PNA properties and applications is reviewed.

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