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. 2004 Feb;17(1):1-6.

Effects of tail suspension on electrophysiological characteristics of muscle spindles in isolated rat soleus muscle

Bin Tang  1 , Xiao-li Fan, Su-di Wu
Affiliations
  • PMID: 15005108

Effects of tail suspension on electrophysiological characteristics of muscle spindles in isolated rat soleus muscle

Bin Tang et al. Space Med Med Eng (Beijing). 2004 Feb.

Abstract

Objective: To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus.

Method: Weightlessness was simulated by tail-suspension in female rats. Using electro-physiological technique, the spontaneous discharge of muscle spindle and its response to ramp-and-hold stretch were observed in isolated soleus of 7 d, 14 d tail-suspended and control rats.

Result: Soleus muscle spindles of rat manifest a sharp decrease in spontaneous discharge frequency and the response to ramp-and-hold stretch after 7 d tail-suspension. More significant changes were observed in rats after 14 d tail-suspension.

Conclusion: Simulated weightlessness could induce time-related changes in electrophysiological characteristics of soleus muscle spindles in rat.

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