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. 2004 Mar 22;14(6):1441-6.
doi: 10.1016/j.bmcl.2004.01.022.

Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization

Robert B Perni  1 , Janos Pitlik, Shawn D Britt, John J Court, Lawrence F Courtney, David D Deininger, Luc J Farmer, Cynthia A Gates, Scott L Harbeson, Rhonda B Levin, Chao Lin, Kai Lin, Young-Choon Moon, Yu-Ping Luong, Ethan T O'Malley, B Govinda Rao, John A Thomson, Roger D Tung, John H Van Drie, Yunyi Wei
Affiliations

Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization

Robert B Perni et al. Bioorg Med Chem Lett. .

Abstract

The alpha-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3.4A protease inhibitors. Structure-activity relationships and prime side optimization are discussed.

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