doi: 10.1016/j.bmcl.2003.12.091.
Synthesis and biological activity of selective azasugar-based TACE inhibitors
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- PMID: 15006405
- DOI: 10.1016/j.bmcl.2003.12.091
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Synthesis and biological activity of selective azasugar-based TACE inhibitors
Bioorg Med Chem Lett.
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Abstract
A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.
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