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. 2004 Mar 9;62(5):815-7.
doi: 10.1212/01.wnl.0000113720.71387.88.

Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance

Cleanthe Spanaki  1 , Andreas Plaitakis
Affiliations

Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance

Cleanthe Spanaki et al. Neurology. .

Abstract

The authors studied Parkinson disease (PD) in natives of Crete, a population sharing a common genetic and cultural background. Analysis of data from 247 index PD cases revealed a hereditary component for PD (OR 3.37; p < 0.001 for a first-degree relative of a PD patient). In 12 bilineal families (PD originating from both parental sides) identified, a high proportion (43%) of bilineal members had PD, but only 5.7% of their offspring were affected. These data suggest a recessive or an oligogenic inheritance for PD.

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