Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Mar;16(3):151-4.

[Study on changes of neuron apoptosis after focal cerebral ischemia/reperfusion in the aged rats]

[Article in Chinese]
Jian-sheng Li  1 , Xiao-qiao Ren, Ke Liu, Zheng-guo Liu, Ling-fei Kong
Affiliations
  • PMID: 15009961

[Study on changes of neuron apoptosis after focal cerebral ischemia/reperfusion in the aged rats]

[Article in Chinese]
Jian-sheng Li et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Mar.

Abstract

Objective: To study ultrastructured change and neuron apoptosis after focal cerebral ischemia/reperfusion (I/R) in the aged rats.

Methods: The aged SD rats (20-21 months) and the young (4-5 months) were subjected to 3 hours of middle cerebral artery occulsion with the intraluminal filament technique, followed by reperfusion for 3 hours, 6 hours, 12 hours, 24 hours, 72 hours. The ultrastructure of brain, infarct zone and neuron apoptosis were observed.

Results: The cerebral infarct zone increased in the aged rats with ischemia for 3 hours and I/R for 12 hours compared with those in the young. The brain injury was obviously deteriorated with I/R time longer, which was serious in the aged than that in the young. The neuron apoptosis increase with I/R time longer, and showed earlier and lasted longer in the aged.

Conclusion: The cerebral injury is serious and neuron apoptosis increase shows early and lasts longer.

PubMed Disclaimer

Publication types