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. 2004 Mar 21:(6):632-3.
doi: 10.1039/b316390c. Epub 2004 Feb 9.

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp

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Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp

Ian Paterson et al. Chem Commun (Camb). .

Abstract

The relative stereochemistry of the 22-membered marine macrolide dictyostatin, a Taxol-like antimitotic agent, was determined based on a combination of extensive high field NMR studies, including J-based configuration analysis, and molecular modelling.

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