Case Reports
doi: 10.1007/BF00465595.
Giant cell tumor of bone. Fine structural localization of alkaline phosphatase
- PMID: 150116
- DOI: 10.1007/BF00465595
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Case Reports
Giant cell tumor of bone. Fine structural localization of alkaline phosphatase
Virchows Arch A Pathol Anat Histol.
.
Abstract
The fine structural localization of nonspecific alkaline phosphatase was elucidated in two giant cell tumors of bone using lead as capturing ion and beta-glycerophosphate as substrate in the incubation solution. Lead phosphate precipitate--indicating presence of alkaline phosphatase--was demonstrated on the plasma membranes, and the membranes bordering vesicles and vacuoles of presumed endocytotic nature, in giant cells and type 1 stromal cells (fibroblast-like cells). The findings support the view that stromal cells type I and giant cells are histogenetically related.
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