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Case Reports
. 1978 Jul 26;378(4):315-20.
doi: 10.1007/BF00465597.

Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis

A Bohle, H Fischbach, H V Gärtner, H von Gise, U Helmchen, K Potjan, E Wildhirt
Case Reports

Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis

A Bohle et al. Virchows Arch A Pathol Anat Histol. .

Abstract

The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I-II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I-III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.

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References

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