Simple estimation of the glomerular filtration rate in sick Thai children

Abstract

The objective of this study was to establish an appropriate formula for the estimation of creatinine clearance (CCr) in sick Thai children, and to evaluate the accuracy of using the Schwartz formula. Children aged between 0 and 19 years with various diseases and varying levels of renal function (but remained stable) were studied. Height in centimetres (L) and weight in kilograms (W), time of urine collection and urine volume were measured to provide urine flow (mL/min (V)) measurements. Body surface area (m2; SA) was also assessed. Quantitative urinary and plasma creatinine concentration (UCr and PCr, respectively) were determined. Creatinine clearance was calculated by using the following formula: UCr x V x 1.73/(PCr x SA). The linear association between CCr and L/PCr derived from these data was compared with the Schwartz formula by using bootstrap statistics. One-hundred and sixty children were studied. A least squares straight-line regression through the origin of CCr against L/PCr provided a good fit to the data. Our dataset revealed no evidence of an age or sex affect on the relationship. Creatinine clearance was estimated by using the following formula: 0.465 x (L/PCr), in which the calculated 95% confidence interval of the coefficient was 0.44-0.49. A comparison of this coefficient with that for the Schwartz formula for children aged > or =1 year (0.55), using 1000 bootstrapped resamples, showed an incompatibility between the two coefficients (P < 0.00005). In conclusion, we suggest estimating CCr in sick Thai children of either sex by using a modification of the Schwartz formula in which the coefficient equals 0.465.