doi: 10.1016/j.bmcl.2003.12.002.
Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles
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- PMID: 15013000
- DOI: 10.1016/j.bmcl.2003.12.002
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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles
Bioorg Med Chem Lett.
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Abstract
The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.
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