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. 2004 Feb 23;14(4):1053-6.
doi: 10.1016/j.bmcl.2003.10.070.

Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists [corrected]

Robin D Clark  1 , Alam Jahangir, Daniel Severance, Rick Salazar, Thomas Chang, David Chang, Mary Frances Jett, Steven Smith, Keith Bley
Affiliations

Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists [corrected]

Robin D Clark et al. Bioorg Med Chem Lett. .

Erratum in

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2697

Abstract

On the basis of screening hits (1a,b), a series of selective, high affinity prostacyclin receptor antagonists was developed. The optimized lead compound 25d [(4,5-dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxybenzyl)phenyl]amine] had analgesic activity in the rat.

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