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Review
. 2004 Feb 6;116(3):351-3.
doi: 10.1016/s0092-8674(04)00121-7.

Active-site dynamics in RNA polymerases

Robert Landick  1
Affiliations
Free article
Review

Active-site dynamics in RNA polymerases

Robert Landick. Cell. .
Free article

Abstract

New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.

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