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Review
. 2004 Mar 15;1677(1-3):113-9.
doi: 10.1016/j.bbaexp.2003.09.018.

Multiple roles for ISWI in transcription, chromosome organization and DNA replication

Davide F V Corona  1 , John W Tamkun
Affiliations
Review

Multiple roles for ISWI in transcription, chromosome organization and DNA replication

Davide F V Corona et al. Biochim Biophys Acta. .

Abstract

ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.

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