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. 2004 Apr;11(4):380-1.
doi: 10.1038/nsmb743. Epub 2004 Mar 14.

A receptor for green tea polyphenol EGCG

Hirofumi Tachibana  1 , Kiyoshi Koga, Yoshinori Fujimura, Koji Yamada
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A receptor for green tea polyphenol EGCG

Hirofumi Tachibana et al. Nat Struct Mol Biol. 2004 Apr.

Abstract

The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value.

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