Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jun;13(6):1031-5.
doi: 10.1128/AAC.13.6.1031.

Streptomycin and Spectinomycin resistance mediated by plasmids

H Kawabe, T Tanaka, S Mitsuhashi

Streptomycin and Spectinomycin resistance mediated by plasmids

H Kawabe et al. Antimicrob Agents Chemother. 1978 Jun.

Abstract

Resistance to tetracycline (Tc), chloramphenicol (Cm), streptomycin (Sm), and sulfanilamide (Sa) was surveyed in clinical isolates of Escherichia coli and Shigella strains. Among the Sm Sa-resistant strains, the frequency of nonconjugative r (Sm Sa) plasmids was much higher than that of conjugative R plasmids encoding double resistance. The biochemical mechanism of Sm resistance mediated by the conjugative plasmids R(Tc Cm Sm Sa) and R(Cm Sm Sa) and about half the numbers of conjugative R(Tc Sm Sa) and R(Sm Sa) plasmids tested were found to be due to adenylylation of the drug. The remaining conjugative R(Tc Sm Sa) and R(Sm Sa) plasmids and all nonconjugative (Sm Sa) plasmids tested inactivated Sm by phosphorylation.

PubMed Disclaimer

References

    1. Antimicrob Agents Chemother. 1977 Sep;12(3):418-22 - PubMed
    1. Antimicrob Agents Chemother. 1975 May;7(5):494-9 - PubMed
    1. Bacteriol Rev. 1972 Sep;36(3):361-405 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2110-4 - PubMed
    1. J Bacteriol. 1969 Nov;100(2):1144-6 - PubMed

LinkOut - more resources