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Editorial
. 2004 Apr;8(2):99-100.
doi: 10.1186/cc2816. Epub 2004 Feb 10.

Coagulation in sepsis: all bugs bite equally

Marcel Levi  1 , Tom van der Poll
Affiliations
Editorial

Coagulation in sepsis: all bugs bite equally

Marcel Levi et al. Crit Care. 2004 Apr.

Abstract

Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder.

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References

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