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Comparative Study
. 2004 Apr;186(2):248-51.
doi: 10.1016/j.expneurol.2003.12.006.

Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

Susan C Fagan  1 , David J Edwards, Cesar V Borlongan, Lin Xu, Ankur Arora, Giora Feuerstein, David C Hess
Affiliations
Comparative Study

Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection

Susan C Fagan et al. Exp Neurol. 2004 Apr.

Abstract

Minocycline is currently under development as a neuroprotective agent in many different brain diseases. In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this route of administration and makes a case for intravenous dosing in experimental animals, particularly for acute neuroprotection, to optimize delivery to the brain and facilitate translation to human studies.

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