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Clinical Trial
. 2004 Mar 22;90(6):1125-8.
doi: 10.1038/sj.bjc.6601700.

Phase I study of cisplatin analogue nedaplatin (254-S) and paclitaxel in patients with unresectable squamous cell carcinoma

I Sekine  1 , H Nokihara, A Horiike, N Yamamoto, H Kunitoh, Y Ohe, T Tamura, T Kodama, N Saijo
Affiliations
Clinical Trial

Phase I study of cisplatin analogue nedaplatin (254-S) and paclitaxel in patients with unresectable squamous cell carcinoma

I Sekine et al. Br J Cancer. .

Abstract

The recommended phase II dose of paclitaxel 180 mg m(-2) given as a 3-h infusion followed by nedaplatin 100 mg m(-2) in a 1-h infusion every 3-4 weeks was determined in 52 chemo-naive patients with unresectable squamous cell carcinoma (SCC), with a promising response rate for lung SCC of 55%.

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