Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Mar-Apr;55(2):155-8.
doi: 10.1177/000331970405500207.

Sex difference in the effect of ACE-DD genotype on the risk of premature myocardial infarction

Daniel Petrovic  1 , Dejan Bregar, Barbara Guzic-Salobir, Erik Skof, Matjaz Span, Rifet Terzić, Mojca Globocnik Petrovic, Irena Keber, Mitja Letonja, Marjeta Zorc, Matej Podbregar, Borut Peterlin
Affiliations

Sex difference in the effect of ACE-DD genotype on the risk of premature myocardial infarction

Daniel Petrovic et al. Angiology. 2004 Mar-Apr.

Abstract

In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.

PubMed Disclaimer

Substances

LinkOut - more resources