Review
doi: 10.1016/0968-0004(92)90381-i.
Bacterial protein translocation: kinetic and thermodynamic role of ATP and the protonmotive force
Affiliations
- PMID: 1502724
- DOI: 10.1016/0968-0004(92)90381-i
Item in Clipboard
Review
Bacterial protein translocation: kinetic and thermodynamic role of ATP and the protonmotive force
Trends Biochem Sci.
1992 Jun.
Abstract
The energetic mechanism of preprotein export in Escherichia coli has been a source of controversy for many years. In vitro studies of translocation reactions that use purified soluble and membrane components have not clarified the main features of this mechanism. Translocation occurs through consecutive steps which each have distinct energy requirements. Initiation of translocation requires ATP and the SecA protein. Most of the further steps can be driven by the protonmotive force (delta p).
Similar articles
-
The catalytic cycle of the escherichia coli SecA ATPase comprises two distinct preprotein translocation events.EMBO J. 1997 Dec 15;16(24):7297-304. doi: 10.1093/emboj/16.24.7297. EMBO J. 1997. PMID: 9405359 Free PMC article.
-
Delta mu H+ and ATP function at different steps of the catalytic cycle of preprotein translocase.Cell. 1991 Mar 8;64(5):927-39. doi: 10.1016/0092-8674(91)90317-r. Cell. 1991. PMID: 1825804
-
SecA protein: autoregulated ATPase catalysing preprotein insertion and translocation across the Escherichia coli inner membrane.Mol Microbiol. 1993 Jan;7(2):159-65. doi: 10.1111/j.1365-2958.1993.tb01107.x. Mol Microbiol. 1993. PMID: 8446024 Review.
-
The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.Cell. 1990 Aug 24;62(4):649-57. doi: 10.1016/0092-8674(90)90111-q. Cell. 1990. PMID: 2167176
-
In vitro translocation of bacterial secretory proteins and energy requirements.J Bioenerg Biomembr. 1990 Jun;22(3):389-99. doi: 10.1007/BF00763174. J Bioenerg Biomembr. 1990. PMID: 2202724 Review.
Cited by
-
Competition between Sec- and TAT-dependent protein translocation in Escherichia coli.EMBO J. 1999 Jun 1;18(11):2982-90. doi: 10.1093/emboj/18.11.2982. EMBO J. 1999. PMID: 10357811 Free PMC article.
-
Secretion of nuclease across the outer membrane of Serratia marcescens and its energy requirements.J Bacteriol. 1997 Feb;179(3):677-83. doi: 10.1128/jb.179.3.677-683.1997. J Bacteriol. 1997. PMID: 9006020 Free PMC article.
-
The archaeal Sec-dependent protein translocation pathway.Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):919-27. doi: 10.1098/rstb.2003.1461. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15306407 Free PMC article. Review.
-
The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation.EMBO J. 1997 Oct 15;16(20):6105-13. doi: 10.1093/emboj/16.20.6105. EMBO J. 1997. PMID: 9321390 Free PMC article.
-
Thylakoid targeting of Tat passenger proteins shows no delta pH dependence in vivo.EMBO J. 2003 Feb 17;22(4):807-15. doi: 10.1093/emboj/cdg081. EMBO J. 2003. PMID: 12574117 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
