Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen
- PMID: 15030
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Lipopolysaccharide-induced suppression of the primary immune response to a thymus-dependent antigen
J Immunol.
1977 Mar.
Abstract
The immune response to a thymus-dependent antigen was depressed in vivo and in vitro in spleen cells from mice injected with LPS i.p. a few days before challenge with the antigen. Spleen cells from LPS-injected mice could, however, respond with increase DNA synthesis after activation with polyclonal B and T cell activators in vitro. The LPS-activated spleen cells could actively suppress normal cells in their response to the antigen sheep red blood cells. The suppressor cells contained in the LPS-activated spleens were most likely B lymphocytes, and the possible mechanism for their inhibitory function is discussed.
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