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. 2004 Feb;10(2):176-8.
doi: 10.3201/eid1002.030533.

SARS-related virus predating SARS outbreak, Hong Kong

Bo Jian Zheng  1 , Ka Hing Wong, Jie Zhou, Kin Ling Wong, Betty Wan Y Young, Li Wei Lu, Shui Shan Lee
Affiliations

SARS-related virus predating SARS outbreak, Hong Kong

Bo Jian Zheng et al. Emerg Infect Dis. 2004 Feb.

Abstract

Using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and/or animal SARS-CoV-like virus in 17 (1.8%) of 938 adults recruited in 2001. This finding suggests that a small proportion of healthy persons in Hong Kong had been exposed to SARS-related viruses at least 2 years before the recent SARS outbreak.

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Figures

Figure
Figure
Correlation between antibodies against human severe acute respiratory syndrome cornonavirus (SARS-CoV) (anti-Hu SARS-CoV) and animal (anti-An) SARS-CoV–like virus in seropositive healthy adults recruited in 2001 (dotted line) and in patients with SARS in 2003 (thick line) by an immunofluorescence (A) and a neutralization (B) assay; and between neutralizing (NT) and immunofluorescence (IF) antibodies against Hu SARS-CoV (C) and a SARS-CoV–like virus (D).
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