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. 2003 Dec:1010:304-6.
doi: 10.1196/annals.1299.053.

1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines

Ravi Shankar Akundi  1 , Michael Hüll, Hans Willi Clement, Bernd L Fiebich
Affiliations

1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines

Ravi Shankar Akundi et al. Ann N Y Acad Sci. 2003 Dec.

Abstract

The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.

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