doi: 10.1196/annals.1299.091.
An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival
Affiliations
- PMID: 15033778
- DOI: 10.1196/annals.1299.091
Item in Clipboard
An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival
Ann N Y Acad Sci.
2003 Dec.
Abstract
We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B(*)Q0) and C3 (C3(*)F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B(*)Q0 on health or survival.
Similar articles
-
A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival.Hum Genet. 1991 Apr;86(6):595-8. doi: 10.1007/BF00201547. Hum Genet. 1991. PMID: 2026423
-
Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris.Immunol Lett. 2002 Mar 1;80(3):145-9. doi: 10.1016/s0165-2478(01)00317-0. Immunol Lett. 2002. PMID: 11803045
-
C4 polymorphism and extended HLA haplotypes in Namibian San and Khoi and in South African Xhosa.Tissue Antigens. 1996 Feb;47(2):111-16. doi: 10.1111/j.1399-0039.1996.tb02522.x. Tissue Antigens. 1996. PMID: 8851723
-
Inherited deficiency of the fourth component of human complement.Immunodefic Rev. 1988;1(1):3-22. Immunodefic Rev. 1988. PMID: 3078708 Review.
-
Complement genetics and host defence.Zentralbl Bakteriol. 1990 Dec;274(3):316-24. doi: 10.1016/s0934-8840(11)80688-2. Zentralbl Bakteriol. 1990. PMID: 2151023 Review.
Cited by
-
Investigation of complement component C4 copy number variation in human longevity.PLoS One. 2014 Jan 22;9(1):e86188. doi: 10.1371/journal.pone.0086188. eCollection 2014. PLoS One. 2014. PMID: 24465950 Free PMC article.
-
The emergence of human-evolutionary medical genomics.Evol Appl. 2011 Mar;4(2):292-314. doi: 10.1111/j.1752-4571.2010.00156.x. Epub 2010 Oct 12. Evol Appl. 2011. PMID: 25567974 Free PMC article.
-
Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality.Clin Exp Immunol. 2007 Jul;149(1):132-8. doi: 10.1111/j.1365-2249.2007.03391.x. Epub 2007 Apr 11. Clin Exp Immunol. 2007. PMID: 17425651 Free PMC article.
-
A systems biology approach to the effect of aging, immunosenescence and vaccine response.Curr Opin Immunol. 2014 Aug;29:62-8. doi: 10.1016/j.coi.2014.04.005. Epub 2014 May 13. Curr Opin Immunol. 2014. PMID: 24820347 Free PMC article. Review.
-
Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene.PLoS One. 2016 Dec 19;11(12):e0167753. doi: 10.1371/journal.pone.0167753. eCollection 2016. PLoS One. 2016. PMID: 27992450 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
