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. 1992 Apr;36(4):867-9.
doi: 10.1128/AAC.36.4.867.

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci

M Arthur  1 , C Molinas, T D Bugg, G D Wright, C T Walsh, P Courvalin
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Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci

M Arthur et al. Antimicrob Agents Chemother. 1992 Apr.

Abstract

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.

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References

    1. Science. 1964 Nov 6;146(3645):775-7 - PubMed
    1. Gene. 1991 Jul 15;103(1):133-4 - PubMed
    1. Antimicrob Agents Chemother. 1991 Apr;35(4):605-9 - PubMed
    1. J Biol Chem. 1989 Feb 15;264(5):2393-6 - PubMed
    1. J Bacteriol. 1974 Feb;117(2):360-72 - PubMed

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