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Review
. 2004 Jun;130(6):307-19.
doi: 10.1007/s00432-003-0530-y. Epub 2004 Mar 18.

Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives

Hui-Chuan Sun  1 , Zhao-You Tang
Affiliations
Review

Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives

Hui-Chuan Sun et al. J Cancer Res Clin Oncol. 2004 Jun.

Abstract

Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. Many angiogenic factors have been studied in HCC, and several anti-angiogenic therapies have been tested in animal models and patients. This paper summarizes the latest findings, especially regarding the clinical significance of endothelial cell markers and angiogenic factors in HCC, and experimental and clinical anti-angiogenesis therapies. Further developments in this area, such as endothelial cell-oriented research and better experimental and clinical designs in the evaluation of anti-angiogenic therapies are discussed.

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