Review
doi: 10.1016/0896-8411(92)90026-m.
T cell activation and antigen presentation in human thyroid autoimmunity
Affiliations
- PMID: 1503607
- DOI: 10.1016/0896-8411(92)90026-m
Item in Clipboard
Review
T cell activation and antigen presentation in human thyroid autoimmunity
J Autoimmun.
1992 Apr.
Abstract
In 1983, a hypothesis concerning the relevance of class II expression and antigen presentation to the induction and maintenance of endocrine autoimmunity was published. This article reviews the evidence that has been marshalled to support this concept, both in man, chiefly in Graves' disease, and in murine systems. New data concerning the multiplicity of thyroid autoantigens recognized by in vivo activated thyroid infiltrating T cells are compatible with this concept since the thyroid epithelial cells are the source of these antigens. Whether other autoimmune diseases also employ the same mechanism remains to be ascertained, as does the initial trigger for the autoimmune process.
Similar articles
-
Thyroid autoantigen-induced lymphocyte proliferation in Graves' disease and Hashimoto's thyroiditis.J Clin Lab Immunol. 1985 May;17(1):1-6. J Clin Lab Immunol. 1985. PMID: 3876444
-
The production and characterization of thyroid-derived T-cell lines in Graves' disease and Hashimoto's thyroiditis.Clin Immunol Immunopathol. 1986 Apr;39(1):139-50. doi: 10.1016/0090-1229(86)90213-8. Clin Immunol Immunopathol. 1986. PMID: 3485022
-
Evidence for thyroid antigen-reactive T lymphocytes infiltrating the thyroid gland in Graves' disease.Clin Endocrinol (Oxf). 1979 Jul;11(1):59-68. doi: 10.1111/j.1365-2265.1979.tb03046.x. Clin Endocrinol (Oxf). 1979. PMID: 391444
-
Autoimmune thyroid disease--a perspective.Mol Biol Med. 1986 Feb;3(1):25-51. Mol Biol Med. 1986. PMID: 2870410 Review.
-
Autoimmunity of thyroid disease. With emphasis on Graves' disease.Neth J Med. 1985;28(1):32-9. Neth J Med. 1985. PMID: 2858065 Review. No abstract available.
Cited by
-
Genetic background and environment contribute synergistically to the onset of autoimmune diseases.J Mol Med (Berl). 1995 Aug;73(8):381-93. doi: 10.1007/BF00240137. J Mol Med (Berl). 1995. PMID: 8528740 Review.
-
Autoantigens in thyroid diseases.Springer Semin Immunopathol. 1993;14(3):285-307. doi: 10.1007/BF00195979. Springer Semin Immunopathol. 1993. PMID: 7679802 Review.
-
Suppression of autoimmune thyroid disease by FK 506: influence on thyroid-infiltrating cells, adhesion molecule expression and anti-thyroglobulin antibody production.Clin Exp Immunol. 1993 Mar;91(3):368-75. doi: 10.1111/j.1365-2249.1993.tb05911.x. Clin Exp Immunol. 1993. PMID: 7680293 Free PMC article.
-
PINTnet: construction of condition-specific pathway interaction network by computing shortest paths on weighted PPI.BMC Syst Biol. 2017 Mar 14;11(Suppl 2):15. doi: 10.1186/s12918-017-0387-3. BMC Syst Biol. 2017. PMID: 28361687 Free PMC article.
-
HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells.Clin Exp Immunol. 1999 Apr;116(1):62-9. doi: 10.1046/j.1365-2249.1999.00831.x. Clin Exp Immunol. 1999. PMID: 10209506 Free PMC article.