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. 2004 Apr;3(2):81-4.
doi: 10.1111/j.1474-9728.2004.00089.x.

Perspectives on herpes-APP interactions

E L Bearer

Perspectives on herpes-APP interactions

E L Bearer. Aging Cell. 2004 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Hypothetical pathway of HSV transport to the brain via bipolar neurons in the trigeminal ganglion. HSV type 1 enters the sensory nerve terminals in the mucous membranes of the face by fusing viral envelope with the neuronal surface membrane. The viral nucleocapsid and tegument is then transported within the neuron back to its cell body in the trigeminal ganglion adjacent to the brain stem where it enters latency or is replicated. After replication in the neuronal nucleus (N), viral particles recruit cellular membranes containing APP, probably during packaging in the Golgi. The sensory neurons of the trigeminal nerve are bipolar, extending a single process that reaches both outwards to the face and inwards to the brain. Thus, newly synthesized virus emerging from the bipolar cell body could be transported either outwards to the face or inwards to enter the brain. In the brain, infective virus may bud from the neuron at the synpase where it has access across the cleft to the post-synaptic neuron. APP, released from virus, could then be hydrolysed and deposit in the synaptic cleft as amyloid.
See this image and copyright information in PMC

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