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Review
. 2004 Feb;4(2):110-22.
doi: 10.1038/nri1268.

Role of the cytoskeleton during leukocyte responses

Miguel Vicente-Manzanares  1 , Francisco Sánchez-Madrid
Affiliations
Review

Role of the cytoskeleton during leukocyte responses

Miguel Vicente-Manzanares et al. Nat Rev Immunol. 2004 Feb.

Abstract

The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that regulates most cellular functions that are related to the immune response, including migration, extravasation, antien recognition, activation and phagocytosis by different subsets of leukocytes. Recently, a large number of regulatory elements and structural constituents of the leukocyte cytoskeleton have been identified. In this review, we discuss the composition and regulation of the different cytoskeletal elements and their role in immune responses.

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