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. 2004 Mar 25;2(1):3.
doi: 10.1186/1477-044X-2-3.

Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma

Fumiko Matsuoka  1 , Masashige Shinkai, Hiroyuki Honda, Tadahiko Kubo, Takashi Sugita, Takeshi Kobayashi
Affiliations

Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma

Fumiko Matsuoka et al. Biomagn Res Technol. .

Abstract

BACKGROUND: We have developed magnetite cationic liposomes (MCLs) and applied them to local hyperthermia as a mediator. MCLs have a positive charge and generate heat under an alternating magnetic field (AMF) by hysteresis loss. In this study, the effect of hyperthermia using MCLs was examined in an in vivo study of hamster osteosarcoma. METHOD: MCLs were injected into the osteosarcoma and then subjected to an AMF. RESULTS: The tumor was heated at over 42 degrees C, but other normal tissues were not heated as much. Complete regression was observed in 100% of the treated group hamsters, whereas no regression was observed in the control group hamsters. At day 12, the average tumor volume of the treated hamsters was about 1/1000 of that of the control hamsters. In the treated hamsters, no regrowth of osteosarcomas was observed over a period of 3 months after the complete regression. CONCLUSION: These results suggest that this treatment is effective for osteosarcoma.

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Figures

Figure 1
Figure 1
Temperature increase at outside of the tumor center (closed circles) and in the rectum (open circles). The temperature at the outside of the tumor center was maintained at 42°C. Data points and bars represent the mean and SD of the 3 independent experiments, respectively.
Figure 2
Figure 2
Time courses of tumor growth after the MCL injection for control (A) and treatment (B) groups. Tumor regrowth was not observed within 3 months in hamsters showing complete regression. ×: The day the hamsters died.
Figure 3
Figure 3
Typical photographs of hamsters on day 20 after the MCL injection. These photographs show one hamster of the treatment (A) group and one of the control group (B).
See this image and copyright information in PMC

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