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. 2004 Mar;67(3):503-5.
doi: 10.1021/np030349a.

New nitrogenous Germacranes from a Thai marine sponge, Axinyssa n. sp

Veena Satitpatipan  1 , Khanit Suwanborirux
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New nitrogenous Germacranes from a Thai marine sponge, Axinyssa n. sp

Veena Satitpatipan et al. J Nat Prod. 2004 Mar.

Abstract

Two new germacrane sesquiterpenes, including (1Z,4Z)-7alphaH-11-aminogermacra-1(10),4-diene (1) and N,N'-11-bis[(1Z,4Z)-7alphaH-germacra-1(10),4-dienyl]urea (2), were isolated from a Thai marine sponge Axinyssan. sp. collected from the Andaman Sea. The structure elucidations of 1 and 2 were accomplished by means of 1D and 2D NMR, MS, and IR spectroscopy. Only 1 exhibited strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans.

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