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Review
. 2004 Apr;32(Pt 2):350-4.
doi: 10.1042/bst0320350.

Physiological functions of protein kinase B/Akt

Z-Z Yang  1 , O Tschopp, A Baudry, B Dümmler, D Hynx, B A Hemmings
Affiliations
Review

Physiological functions of protein kinase B/Akt

Z-Z Yang et al. Biochem Soc Trans. 2004 Apr.

Abstract

The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.

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